the human anti-il-1β monoclonal antibody acz885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis人类anti-il-1β单克隆抗体acz885是有效的在关节炎症小鼠模型和概念验证研究类风湿性关节炎患者.pdf

Available online /content/10/3/R67 Vol 10 No 3 Open Access Research article The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis 1 2 3 3 4 Rieke Alten , Hermann Gram , Leo A Joosten , Wim B van den Berg , Joachim Sieper , 5 6 7 8 8 Siegfrid Wassenberg , Gerd Burmester , Piet van Riel , Maria Diaz-Lorente , Gerardus JM Bruin , 8 8 8 8 8 Thasia G Woodworth , Christiane Rordorf , Yannik Batard , Andrew M Wright and Thomas Jung 1Department of Internal Medicine II, Rheumatology, Schlosspark-Klinik Teaching Hospital Charité University Medicine Berlin, Heubnerweg, D-14059 Berlin, Germany 2Novartis Institutes of Biomedical Research, Basel, CH-4002 Basel, Switzerland 3Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands 4Department of Rheumatology, Klinikum Benjamin Franklin, Hindenburgdamm, D-12200 Berlin, Germany 5Department of Rheumatology, Evangelisches Fachkrankenhaus, Rosenstraße, D-40882 Ratingen, Germany 6Department of Rheumatology, Charité, Charitéplatz, D-10117 Berlin, Germany 7Department of Rheumatology, University Medical Center St Radboud, Nijmegen 6500 HB, The Netherlands 8Novartis Exploratory Development, Werk St. Johann, Forum 1, CH-4002 Basel, Switzerland Corresponding author: Thomas Jung, thomas.jung@ Received: 2 Jan