biomarkers of good eular response to the b cell depletion therapy in all seropositive rheumatoid arthritis patients clues for the pathogenesis生物标志物的欧拉反应b细胞耗竭治疗血清反应阳性的类风湿性关节炎患者发病机制的线索.pdf

Biomarkers of Good EULAR Response to the B Cell Depletion Therapy in All Seropositive Rheumatoid Arthritis Patients: Clues for the Pathogenesis 1 1 2 1 Gianfranco Ferraccioli *, Barbara Tolusso , Francesca Bobbio-Pallavicini , Elisa Gremese , 3 4 ` 5 6 7 Viviana Ravagnani , Maurizio Benucci , Edoardo Podesta , Fabiola Atzeni , Alice Mannocci , 3 4 6 ` 5 Domenico Biasi , Mariangela Manfredi , Piercarlo Sarzi-Puttini , Bruno Lagana , Carlomaurizio Montecucco2 1 Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 2 Division of Rheumatology, University of Pavia, IRCCS S. Matteo Foundation, Pavia, Italy, 3 Department of Clinical and Experimental Medicine, Section of Rheumatology and Internal Medicine, University of Verona, Verona, Italy, 4 Rheumatology Unit, Department of Internal Medicine, Ospedale di S. Giovanni di Dio, Florence, Italy, 5 Division of Clinical Immunology and Rheumatology, II School of Medicine, S. Andrea University Hospital, ‘‘Sapienza’’ University of Rome, Rome, Italy, 6 Rheumatology Unit, University Hospital L. Sacco, Milan, Italy, 7 Unit of Hygiene, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy Abstract Objective: To find out whether a high number of auto-antibodies can increase the probability of a ‘‘good-EULAR response’’ and to identify the possible biomarkers of response in seropositive rheumatoid arthritis (RA) patients undergoing the B cell depletion therapy (BCDT). Patients and Methods: One hundred and thirty-eight patients with lo