somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes线粒体的风湿性关节炎synoviocytes体细胞突变.pdf

Available online /content/7/4/R844 Vol 7 No 4 Open Access Research article Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes 1 2 1 3 1 Tanya R Da Sylva , Alison Connor , Yvonne Mburu , Edward Keystone and Gillian E Wu 1Department of Biology, York University, Toronto, Ontario, Canada 2The Wellesley Toronto Arthritis and Immune Disorder Research Centre, University Health Network, Toronto, Ontario, Canada 3Department of Medicine, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada Corresponding author: Tanya R Da Sylva, dasylva@yorku.ca Received: 19 Nov 2004 Revisions requested: 22 Dec 2004 Revisions received: 29 Mar 2005 Accepted: 31 Mar 2005 Published: 28 Apr 2005 Arthritis Research Therapy 2005, 7:R844-R851 (DOI 10.1186/ar1752) This article is online at: /content/7/4/R844 © 2005 Da Sylva et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Somatic mutations have a role in the pathogenesis of a number To test the hypothesis that mutations in mitochondrial DNA of diseases, particularly cancers. Here we present data (mtDNA) are associated with RA, we focused on the MT-ND1 supporting a role of mitochondrial somatic mutations in an gene for mitochondrially encoded NADH dehydrogenase 1 autoimmune disease, rheumatoid arthritis (RA). RA i