the effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients英夫利昔单抗治疗的效果在类风湿性关节炎患者的血清蛋白质组.pdf

Available online /content/11/2/R32 Vol 11 No 2 Open Access Research article The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients 1,2 2 1,2 1,2 1,2 Ravi C Dwivedi , Navjot Dhindsa , Oleg V Krokhin , John Cortens , John A Wilkins and Hani S El-Gabalawy1,2 1Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, 799-715 McDermot Avenue, Winnipeg, MB, R3E 3P4, Canada 2Department of Internal Medicine, University of Manitoba, RR149-800 Sherbrook Street, Winnipeg, MB, R3A 1M4, Canada Corresponding author: Hani S El-Gabalawy, elgabalh@cc.umanitoba.ca Received: 7 Jan 2009 Revisions requested: 30 Jan 2009 Revisions received: 25 Feb 2009 Accepted: 6 Mar 2009 Published: 6 Mar 2009 Arthritis Research Therapy 2009, 11:R32 (doi:10.1186/ar2637) This article is online at: /content/11/2/R32 © 2009 Dwivedi et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Although the clinical effects of infliximab therapy in Results An average of 373 distinct proteins were identified per rheumatoid arthritis have been documented extensively, the patient with greater than 95% confidence. In the 3 patients biological effects of this intervention continue to be defined. We demonstrating the most robust clinical