targeting b cells for the treatment of rheumatoid arthritis针对b细胞治疗类风湿性关节炎.pdf
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Review
Targeting B cells for the treatment of rheumatoid arthritis
Thomas J Oligino and Stacie A Dalrymple
Roche Pharmaceuticals, Palo Alto, California, USA
Correspondence: Thomas Oligino (e-mail: tom.oligino@)
Received: 30 Jul 2003 Revisions requested: 4 Aug 2003 Revisions received: 15 Aug 2003 Accepted: 19 Aug 2003 Published: 2 Oct 2003
Arthritis Res Ther 2003, 5(Suppl 4):S7-S11 (DOI 10.1186/ar1006)
© 2003 BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362)
Abstract
The role of B cells in rheumatoid arthritis (RA) has been debated for decades. However, recent clinical
trial data indicating that depletion of B cells in RA patients is of therapeutic benefit has validated the
importance of this cell type in the pathogenesis of the disease. Elucidation of the molecular basis of
B cell development and activation has allowed the identification of a number of possible therapeutic
targets that are appealing for drug development. This review discusses briefly a number of these
molecules and the rationale for targeting them for the treatment of RA.
Keywords: autoimmunity, arthritis, B cells
Introduction techniques, the main thrust of this article is to discuss
Rheumatoid arthritis (RA) is a complex disease of some of the more prominent targets that allow modulation
unknown etiology. Decades of research into the pathogen- of the B cell response.
esis of the disease have elucidated a number of the key
pathways involved in the generation of the disease state. B cell depletion
Fr
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