the contact-mediated response of peripheral-blood monocytes to preactivated t cells is suppressed by serum factors in rheumatoid arthritis外周血单核细胞的contact-mediated响应preactivated t细胞是由血清抑制类风湿性关节炎的因素.pdf

Available online /content/7/6/R1189 Vol 7 No 6 Open Access Research article The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis 1 1 2 1 3 Manuela Rossol , Sylke Kaltenhäuser , Roger Scholz , Holm Häntzschel , Sunna Hauschildt and Ulf Wagner1 1Department of Medicine IV, University of Leipzig, Leipzig, Germany 2Department of Orthopedics, University of Leipzig, Leipzig, Germany 3Department of Immunobiology, Institute of Zoology, University of Leipzig, Leipzig, Germany Corresponding author: Ulf Wagner, wagu@medizin.uni-leipzig.de Received: 3 Mar 2005 Revisions requested: 17 Mar 2005 Revisions received: 16 Jul 2005 Accepted: 20 Jul 2005 Published: 17 Aug 2005 Arthritis Research Therapy 2005, 7:R1189-R1199 (DOI 10.1186/ar1804) This article is online at: /content/7/6/R1189 © 2005 Rossol et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Stimulation of monocytes/macrophages after cell contact with response of peripheral-blood monocytes from patients with RA preactivated T cells has been suggested to contribute to the was found to be mediated by inhibitory serum factors, because excessive TNF-α production in rheumatoid arthritis (RA). In this the addition of patient sera to monocytes from healthy controls study, T cell-contact-depende