synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing mcp-1 and il-8类风湿性关节炎患者滑膜基质细胞吸引单核细胞生产mcp-1和引发.pdf

Available online /content/3/2/118 Primary research Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8 Kenji Hayashida*, Toshihiro Nanki*, Hermann Girschick*, Sule Yavuz*, Takahiro Ochi† and Peter E Lipsky* *University of Texas, Southwestern Medical Center, Dallas, Texas, USA †Osaka University Medical School, Suita, Osaka, Japan Correspondence: Peter E Lipsky, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 9000 Rockville Pike, Bldg 10, Room 9N 228, Bethesda, MD 20892, USA. Tel: +1 301 496 2612; fax: +1 301 402 0012; e-mail: lipskyp@ Received: 23 August 2000 Arthritis Res 2001, 3:118–126 Revisions requested: 18 September 2000 This article may contain supplementary data which can only be found Revisions received: 22 November 2000 online at /content/3/2/118 Accepted: 4 December 2000 © 2001 Hayashida et al, licensee BioMed Central Ltd Published: 5 January 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the infl