synovial expression of il-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor在类风湿性关节炎滑膜表达il-15并不受封锁的肿瘤坏死因子的影响.pdf

Available online /content/8/1/R18 Vol 8 No 1 Open Access Research article Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor 1 2 2 3 2 Sofia Ernestam , Erik af Klint , Anca Irinel Catrina , Erik Sundberg , Marianne Engström , Lars Klareskog2 and Ann-Kristin Ulfgren2 1Department of Rheumatology, Karolinska University Hospital, S-141 86 Stockholm, Sweden 2Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden 3Department of Women and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden Corresponding author: Sofia Ernestam, sofia.ernestam@karolinska.se Received: 8 Jul 2005 Revisions requested: 16 Aug 2005 Revisions received: 6 Oct 2005 Accepted: 21 Nov 2005 Published: 28 Dec 2005 Arthritis Research Therapy 2006, 8:R18 (doi:10.1186/ar1871) This article is online at: /content/8/1/R18 © 2005 Ernestam et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Blockade of tumour necrosis factor (TNF) is an effective analysis. IL-15 expression was detected in all synovial biopsies treatment in rheumatoid arthritis (RA), but both non-responders taken at baseline. After infliximab therapy, the expression of IL- and partial responders are quite fre