th-17 cells in rheumatoid arthritisth17细胞在类风湿性关节炎.pdf

Available online /content/10/4/R93 Vol 10 No 4 Open Access Research article TH-17 cells in rheumatoid arthritis 1 1 1 1,2 Shiva Shahrara , QiQuan Huang , Arthur M Mandelin II and Richard M Pope 1Department of Medicine, Feinberg School of Medicine, Northwestern University 240 E. Huron, Suite M220, Chicago, IL 60611, USA 2Jesse Brown VA Chicago Healthcare System, 820 S. Damon, Chicago, IL 60612, USA Corresponding author: Shiva Shahrara, s-shahrara@ Received: 15 May 2008 Revisions requested: 11 Jun 2008 Revisions received: 8 Aug 2008 Accepted: 18 Aug 2008 Published: 18 Aug 2008 Arthritis Research Therapy 2008, 10:R93 (doi:10.1186/ar2477) This article is online at: /content/10/4/R93 © 2008 Shahrara et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The aim of this study was to quantify the number PB and RA SF. With or without P/I plus IL-23, the percentage of of T-helper (TH)-17 cells present in rheumatoid arthritis (RA) TH-17 cells was higher in RA SF compared with normal and RA synovial fluid (SF) and to determine the level of interleukin (IL)- PB. IL-17 levels were comparable in OA and normal synovial 17 cytokine in RA, osteoarthritis (OA) and normal synovial tissues, and these values were significantly increased in RA tissue, as well as to examine SF macrophages for t