the association between disease activity and nt-probnp in 238 patients with rheumatoid arthritis a 10-year longitudinal study疾病活动之间的关系,类风湿性关节炎患者中位数水平以上病人在238年10年的纵向研究.pdf

Available online /content/10/3/R70 Vol 10 No 3 Open Access Research article The association between disease activity and NT-proBNP in 238 patients with rheumatoid arthritis: a 10-year longitudinal study 1 2,3 1 1 2,3 Sella A Provan , Kristin Angel , Sigrid Ødegård , Petter Mowinckel , Dan Atar and Tore K Kvien1,2 1Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vindern, N-0319 Oslo, Norway 2Faculty of Medicine, University of Oslo, Pb1018 0316 Oslo, Norway 3Aker University Hospital, Division of Cardiology, University of Oslo, Trondheimsveien 235, 0514 Oslo, Norway Corresponding author: Sella A Provan, s-provan@diakonsyk.no Received: 29 Jan 2008 Revisions requested: 13 Feb 2008 Revisions received: 12 May 2008 Accepted: 23 Jun 2008 Published: 23 Jun 2008 Arthritis Research Therapy 2008, 10:R70 (doi:10.1186/ar2442) This article is online at: /content/10/3/R70 © 2008 Provan et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Disease activity in patients with rheumatoid Results C-reactive protein (CRP) levels at baseline were cross- arthritis (RA) is associated with increased cardiovascular sectionally associated with NT-proBNP levels after adjustment morbidity and mortality, of which N-terminal pro-brain natriuretic for age and gender (r2 adjuste