association of nt-probnp and multiple biomarkers with severity of angiographic coronary artery disease in diabetic and pre-diabetic chinese patients中位数水平以上病人协会和多个生物标志物与血管造影冠状动脉疾病的严重程度在中国糖尿病和糖尿病患者.pdf

Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients 2,4 1 . 1 1 3 . 3 1 Zhou Fang , Linuo Zhou * , Yuanyuan Bao , Wei Ding , Haiming Shi * , Xinping Luo , Renming Hu 1 Department of Endocrinology and Metabolism, Huashan Hospital of Fudan University, Shanghai, China, 2 Institute of Endocrinology and Diabeteology, Shanghai, China, 3 Department of Cardiology, Huashan Hospital at Fudan University, Shanghai, China, 4 State Key Laboratory of Genetic Engineering, Shanghai, China Abstract Background: Little is known about the plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), and the relationship between the severity of coronary heart disease (CHD) with NT-proBNP and multiple biomarkers in diabetic and pre-diabetic patients, compared to individuals with normal glucose levels. Methods: Four hundred and fifteen consecutive Chinese patients of both sexes were assigned to three groups on the basis of the new hemoglobin (Hb) A1c (HbA1c) cut-off points for diagnosis of diabetes and pre-diabetes. The three groups were divided into tertiles according to NT-proBNP, hs-CRP, cystatin C, and troponin T levels. Gensini scores were compared among the three groups and biomarker tertiles. Receiver operating characteristic (ROC) curves were used to obtain the angiographic CHD cut-off points for each biomarker. Stepwise multivariate linear correlation analysis was applied to examine the association between the severity of CHD and biomarker levels. Results: Gensini scores increased with increasing biomarker tertile levels and HbA1c. Gensini scores