association of snp rs6903956 on chromosome 6p24.1 with angiographical characteristics of coronary atherosclerosis in a chinese population协会的snp rs6903956 6号染色体上p24.1动脉血管摄影有其与冠状动脉粥样硬化的特点在中国人口.pdf

Association of SNP Rs6903956 on Chromosome 6p24.1 with Angiographical Characteristics of Coronary Atherosclerosis in a Chinese Population Chang-Yan Guo., Yan Gu., Li Li, En-Zhi Jia*, Chun-Jian Li, Lian-Sheng Wang, Zhi-Jian Yang, Ke-Jiang Cao, Wen-Zhu Ma Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China Abstract Objective: To explore the association between rs6903956 and severity of coronary artery disease (CAD) in a Chinese population. Methods: A cohort of 1075 consecutive patients who underwent coronary arteriography for suspected or known coronary atherosclerosis was enrolled in our study. Coronary atherosclerosis severity was defined by Gensini’s Score System and counts of diseased vessels. Results: Gensini score frequencies and counts of diseased vessels differed among GG, AG, AA genotype groups at the rs6903956 locus (p = 0.025 for Gensini score frequencies vs. p = 0.024 for counts of diseased vessels, respectively). A univariate logistic regression analysis revealed that the genotype distribution of this SNP was associated significantly with angiographical characteristics of coronary atherosclerosis risk (p = 0.030, odds ratio (OR) = 1.444, 95% confidence interval (CI) = 1.036,2.013 for AG vs. GG; p = 0.021, OR = 5.896, 95% CI = 1.299,26.750 for AA vs. GG and p = 0.007, OR = 1.564, 95% CI = 1.132,2.162 for combined (AG+AA) vs. GG). A multivariate logistic regression analysis indicated that the genotype distribution of the rs6903956 polymorphism be associated significantly with the angiographical characteristics of coronary atherosclerosis risk (p = 0.004, OR = 1.578, 95% CI = 1.155,2.154 for GG vs. AG vs. AA; p = 0.013, OR = 1.541, 95% CI = 1.097,2.163 f