association of the il-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (jia)协会,il - 10基因家族的轨迹与幼年特发性关节炎(贾庆林)1号染色体上.pdf

Association of the IL-10 Gene Family Locus on Chromosome 1 with Juvenile Idiopathic Arthritis (JIA) 1 . 2. 1 1 3 4 Ebun Omoyinmi * , Paola Forabosco , Raja Hamaoui , Annette Bryant , Anne Hinks , Simona Ursu , { { Childhood Arthritis Prospective Study (CAPS) , BSPAR study group , Childhood Arthritis Response to { 4 3 5,6 Medication Study (CHARMS) , Lucy R. Wedderburn , Wendy Thomson , Cathryn M. Lewis , Patricia Woo1 1 Department of Immunology and Molecular Pathology, University College London, London, United Kingdom, 2 Istututo di Genetica delle Popolazioni, CNR, Sassari, Italy, 3 Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 4 Rheumatology Unit, Institute of Child Health, University College London, London, United Kingdom, 5 King’s College London, Department of Medical and Molecular Genetics, London, United Kingdom, 6 King’s College London, MRC SGDP Centre, Institute of Psychiatry, London, United Kingdom Abstract Background: The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). The aim of this study was to fine map genetic variants within the IL-10 cytokine family cluster on chromosome 1 using linkage disequilibrium (LD)-tagging sing