t-cell activation without proliferation in juvenile idiopathic arthritist细胞激活在青少年特发性关节炎没有扩散.pdf

Available online /content/4/3/177 Research article T-cell activation without proliferation in juvenile idiopathic arthritis 1 2† 3 3 Antony PB Black , Hansha Bhayani , Clive AJ Ryder , Janet MM Gardner-Medwin and Taunton R Southwood4 1MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK 2Formerly of Department of Rheumatology, University of Birmingham 3Department of Paediatric Rheumatology, Birmingham Children’s Hospital-NHS Trust, Birmingham, UK 4Department of Rheumatology, University of Birmingham, Edgbaston, Birmingham, UK †Deceased. Correspondence: Professor Taunton R Southwood, Department of Rheumatology, University of Birmingham, St Vincent’s Drive, Edgbaston, Birmingham, B15 2TT, UK. Tel: +44 (0)121 414 6778; fax: +44 (0)121 414 6794; e-mail: t.r.southwood@bham.ac.uk Received: 21 February 2001 Arthritis Res 2002, 4:177-183 Revisions requested: 4 April 2001 This article may contain supplementary data which can only be found Revisions received: 7 August 2001 online at /content/4/3/177 Accepted: 31 August 2001 © 2002 Black et al., licensee BioMed Central Ltd Published: 21 November 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract A study was done to determine if the differentiation and activation phenotype of T cells in synovial fluid (SF) from patients with juvenile idiopathic arthritis (JIA) is associated with T-cell prolifer