association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population六个单核苷酸多态性与妊娠期糖尿病协会在中国人口.pdf

Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population 1,2 1 1 1 1 3 3 3 Ying Wang , Min Nie *, Wei Li , Fan Ping , Yingying Hu , Liangkun Ma , Jinsong Gao , Juntao Liu 1 Key laboratory of Endocrine, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China, 2 Department of Endocrinology, the Secondly Affiliated Hospital of ShanXi Medical College, Shan Xi, China, 3 Department of Obstetrics Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing China Abstract Background: To investigate whether the candidate genes that confer susceptibility to type 2 diabetes mellitus are also correlated with gestational diabetes mellitus (GDM) in pregnant Chinese women. Methodology/Principal Findings: In this study, 1764 unrelated pregnant women were recruited, of which 725 women had GDM and 1039 served as controls. Six single nucleotide polymorphisms (rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, r in MTNR1B, rs4607517 in GCK) were genotyped using TaqMan allelic discrimination assays. The genotype and allele distributions of each SNP between the GDM cases and controls and the combined effects of alleles for the risk of developing GDM were analyzed. We found that the rs4402960, rs2383208 and rs391300 were statistically associated with GDM (OR = 1.207, 95%CI = 1.029–1.417, p = 0.021; OR = 1.242, 95%CI = 1.077– 1.432, p = 0.003; OR = 1.202, 95%CI = 1.020–1.416, P = 0.028, respectiv