association between single nucleotide polymorphisms in ercc4 and risk of squamous cell carcinoma of the head and neck联系单核苷酸多态性在ercc4和头颈部鳞状细胞癌的风险.pdf

Association between Single Nucleotide Polymorphisms in ERCC4 and Risk of Squamous Cell Carcinoma of the Head and Neck 1,2 2 2 2 2 2 Hongping Yu *, Zhensheng Liu , Yu-Jing Huang , Ming Yin , Li-E Wang , Qingyi Wei * 1 Department of Epidemiology and Biostatistics, Guiling Medical University School of Public Health, Guilin, China, 2 Departments of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America Abstract Background: Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide polymorphisms (SNPs) in ERCC4 may impact repair capacity and affect cancer susceptibility. Methodology/Principal Findings: In this case-control study, we evaluated associations of four selected potentially functional SNPs in ERCC4 with risk of squamous cell carcinoma of the head and neck (SCCHN) in 1,040 non-Hispanic white patients with SCCHN and 1,046 cancer-free matched controls. We found that the variant GG genotype of rs2276466 was significantly associated with a decreased risk of SCCHN (OR = 0.69, 95% CI 0.50–0.96), and that the variant TT genotype of rs3136038 showed a borderline significant decreased risk with SCCHN (OR = 0.76, 95% CI: 0.58–1.01) in the recessive model. Such protective effects were more evident in oropharyngeal cancer (OR = 0.61, 95% CI: 0.40–0.92 for rs2276466; OR = 0.69, 95% CI: 0.48–0.98 for rs3136038). No significant associations were found for the other two SNPs (rs1800067 and rs1799798). In addition, individuals with the rs2276466 GG or with the rs3136038 TT genotypes had