association between polymorphisms in the promoter regions of matrix metalloproteinases (mmps) and risk of cancer metastasis a meta-analysis协会之间的多态性的启动子区域里基质金属蛋白酶(mmps)和患癌症的风险转移一个荟萃分析.pdf

Association between Polymorphisms in the Promoter Regions of Matrix Metalloproteinases (MMPs) and Risk of Cancer Metastasis: A Meta-Analysis 1. 1. 2 1 3 1 Dan Liu , Hong Guo , Yafei Li , Xueqing Xu , Kang Yang *, Yun Bai * 1 Department of Medical Genetics, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China, 2 Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China, 3 Department of Thoracic and Cardiac Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China Abstract Background: A variety of studies have evaluated the associations between polymorphisms in the promoter regions of Matrix metalloproteinases (MMPs) and cancer metastasis. However, the results remain inconclusive. To better understand the roles of MMP polymorphisms in metastasis, we conducted a comprehensive meta-analysis. Methods: Electronic databases were searched (from January 2000 to June 2011) for any MMP genetic association studies in metastasis. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between MMP polymorphisms and metastasis. Statistical analysis was performed with Review Manager 5.0 and STATA11.0. Results: Thirty-three studies addressing five MMP polymorphisms were analyzed among 10,516 cancer cases (4,059 metastasis-positive cases and 6,457 metastasis-negative cases). For MMP1 ( 21607)1G/2G, genotype 2G/2G increased the overall risk of metastasis under the recessive model (OR = 1.44, 95% CI = 1.05–1.98). In subgroup analysis based on cancer type, associations were found in head/neck and breas