association of opa1 polymorphisms with ntg and htg a meta-analysis协会opa1多态性ntg和高温凝胶一个荟萃分析.pdf

Association of OPA1 Polymorphisms with NTG and HTG: A Meta-Analysis 1,2,4. 2. 3 2 3 1,5 Yatu Guo , Xia Chen , Hongtuan Zhang , Ningdong Li , Xiong Yang , Wenbo Cheng , Kanxing Zhao2* 1Tianjin Medical University, Tianjin, China, 2 Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China, 3 Second Hospital of Tianjin Medical University, Tianjin, China, 4 Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland, United States of America, 5 Department of Ophthalmology, the People’s Hospital of Changzhi, Shanxi, China Abstract Background: Genetic polymorphisms of the Optic atrophy 1 gene have been implicated in altering the risk of primary open angle glaucoma (POAG), especially the susceptibility to normal tension glaucoma (NTG), but the results remain controversial. Methods: Multiple electronic databases (up to January 20, 2012) were searched independently by two investigators. A meta-analysis was performed on the association between Optic atrophy 1 polymorphisms (rs 166850 and rs and normal tension glaucoma (NTG)/high tension glaucoma (HTG). Summary odds ratios (ORs) and 95% confidence intervals (CI) were estimated. Results: Seven studies of 713 cases and 964 controls for NTG and five studies of 1200 cases and 971 controls for HTG on IVS8+4C.T (rs 166850) and IVS8+32T.C (r were identified. There were significant associations between the OPA1 rolymorphism and NTG susceptibility for all genetic models(C vs. T OR = 1.26, 95% CI 1.09–1.47, p = 0.002; CC vs. TT: OR = 1.52, 95% CI 1.04–2.20, p = 0.029; CC vs. CT+TT: OR = 1.64,