association of gstp1 ile105val polymorphism and risk of head and neck cancers a meta-analysis of 28 case-control studies协会gstp1 ile105val多态性和头部和颈部癌症的风险的荟萃分析28病例对照研究.pdf

Association of GSTP1 Ile105Val Polymorphism and Risk of Head and Neck Cancers: A Meta-Analysis of 28 Case- Control Studies 1. 2. 3 1 1 Juntian Lang , Xicheng Song , Jinwei Cheng , Shuwei Zhao , Jingping Fan * 1 Department of Otorhinolaryngology-Head Neck Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China, 2 Department of Otolaryngology-Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China, 3 Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China Abstract Background and Aims: The Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent. The aim of this study was to evaluate the possible association between the GSTP1 Ile105Val polymorphism and risk of HNC. Method: We performed a search in the relevant electronic database and a meta-analysis based on 28 published case– control studies that included 6,404 cases and 6,523 controls. To take into account the possibility of heterogeneity across the studies, a Chi-square based I2-statistic test was performed. Crude pooled odds ratios (ORs) with 95% confidence intervals (CIs) were assessed using both fixed-effects and random-effects models. Results: The results of this meta-analysis showed that the GSTP1 Ile105Val polymorphism was not significantly associated with risk of HNC in the overall study population (pooled OR 1.00, 95% CI 0.92–1.09) or in subgroup analyses stratified by ethnicity, sample size, tumor site or publication year. Moreover, substantial evidence of heterogeneity among the studies was observed. Publicat