association between chronic obstructive pulmonary disease and lung cancer a case-control study in southern chinese and a meta-analysis慢性阻塞性肺疾病和肺癌之间的联系在中国南部的一个病例对照研究和荟萃分析.pdf

Association between Chronic Obstructive Pulmonary Disease and Lung Cancer: A Case-Control Study in Southern Chinese and a Meta-Analysis 1 1 1 1,3 4 5 3 Hui Wang , Lei Yang , Linnan Zou , Dongsheng Huang , Yuan Guo , Mingan Pan , Yigang Tan , 6 1 2 2 1 Haibo Zhong , Weidong Ji , Pixin Ran , Nanshan Zhong , Jiachun Lu * 1 School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China, 2 Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China, 3 Department of Respiratory Medicine, Guangzhou Chest Hospital, Guangzhou, Guangdong, China, 4 The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, 5 Department of Respiratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China, 6 Department of Respiratory Medicine, Guangzhou Red Cross Hospital, Guangzhou, Guangdong, China Abstract Background: Lung cancer and chronic obstructive pulmonary disease (COPD) share a common risk factor in cigarette smoking and a large portion of patients with lung cancer suffer from COPD synchronously. We therefore hypothesized that COPD is an independent risk factor for lung cancer. Our aim was to investigate the intrinsic linkage of COPD (or emphysema, chronic bronchitis and asthma) and lung cancer. Methods: The present hospital-based case-control study included 1,069 patients with newly diagnosed lung cancer and 1,132 age fr