association between circulating levels of igf-1 and igfbp-3 and lung cancer risk a meta-analysis循环的igf - 1水平与igfbp-3与肺癌风险分析.pdf

Association between Circulating Levels of IGF-1 and IGFBP-3 and Lung Cancer Risk: A Meta-Analysis 1. 2. 2 1 2 1 1,2 Hongxin Cao , Guanghui Wang , Long Meng , Hongchang Shen , Zhen Feng , Qi Liu , Jiajun Du * 1 Institute of Oncology, Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, People’s Republic of China, 2 Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, People’s Republic of China Abstract Background: The insulin-like growth factor (IGF) system was documented to play a predominant role in neoplasia. As lung cancer is one of the most malignant cancers, we conducted a meta-analysis in order to investigate the strength of association between circulating IGF-1 and IGFBP-3 levels and lung cancer. Methodology/Principal Findings: A systematic literature search was conducted to identify all prospective case-control studies and case-control studies on circulating IGFs and IGFBPs levels. Six nested case-control studies (1 043 case subjects and 11 472 control participants) and eight case-control studies (401 case subjects and 343 control participants) were included in this meta-analysis. Pooled measure was calculated as the inverse variance-weighted mean of the natural logarithm of multivariate adjusted OR with 95% CIs for highest vs. lowest levels to assess the association of circulating IGF-1 and IGFBP-3 concentrations and lung cancer. Standard mean difference (SMD) was also calculated to indicate the difference of the circulating IGF-1 and IGFBP-3 concentrations between the lung cancer case group and the control group. Of