associations between interleukin-1 gene polymorphisms and coronary heart disease risk a meta-analysis基因多态性及冠心病风险之间的关联分析.pdf

Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis 1 1 1 2 1 Liang Zhou *, Jianguang Cai , Gang Liu , Yuan Wei , Hui Tang 1 Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan, Hunan, China, 2 Department of Sports Physiology, Guangzhou Sports University, Guangzhou, Guangdong, China Abstract Objective: A great number of studies regarding the associations between IL-1B-511, IL-1B+3954 and IL-1RN VNTR polymorphisms within the IL-1gene cluster and coronary heart disease (CHD) have been published. However, results have been inconsistent. In this study, a meta-analysis was performed to investigate the associations. Methods: Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed- effect model. Results: Thirteen studies (3,219 cases/2,445 controls) for IL-1B-511 polymorphism, nine studies (1,828 cases/1,818 controls) for IL-1B+3954 polymorphism and twelve studies (2,987 cases/ 2,208 controls) for IL-1RN VNTR polymorphism were included in this meta analysis. The results indicated that both IL-1B-511 and IL-1B+3954 polymorphisms were not associated with CHD risk (IL-1B-511 T vs. C: OR = 0.98, 95%CI 0.87–1.09; IL-1B+3954 T vs. C: OR = 1.06, 95%CI 0.95–1.19). Similarly, there was no association between IL-1RN VNTR polymorphism and CHD risk (*2 vs. L: OR = 1.00, 95%CI 0.85–1.17). Conclusions: This meta-analysis suggested that there were no associations between IL-1 gene cluster polymorphisms and CHD. Citation: Zhou L, Cai J, Liu G, Wei Y, Tang H (2012) Associations between Interleukin-1 Gene Polymorphisms