combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis止血作用的基因多态性和心肌梗死的风险患者的冠状动脉粥样硬化.pdf

Combined Effect of Hemostatic Gene Polymorphisms and the Risk of Myocardial Infarction in Patients with Advanced Coronary Atherosclerosis 1 2 3 1 1 1 1 1 Nicola Martinelli , Elisabetta Trabetti , Mirko Pinotti , Oliviero Olivieri , Marco Sandri , Simonetta Friso , Francesca Pizzolo , Claudia Bozzini , 3 2 4 2 3 1 1 Pier Paolo Caruso , Ugo Cavallari , Suzanne Cheng , Pier Franco Pignatti , Francesco Bernardi , Roberto Corrocher , Domenico Girelli * 1 Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy, 2 Section of Biology and Genetics, Department of Mother and Child and Biology–Genetics, University of Verona, Verona, Italy, 3 Department of Biochemistry and Molecular Biology, University of Ferrara , Ferrara, Italy, 4 Department of Human Genetics, Roche Molecular Systems, Inc., Alameda, California, United States of America Background. Relative little attention has been devoted until now to the combined effects of gene polymorphisms of the hemostatic pathway as risk factors for Myocardial Infarction (MI), the main thrombotic complication of Coronary Artery Disease (CAD). The aim of this study was to evaluate the combined effect of ten common prothrombotic polymorphisms as a determinant of MI. Methodology/Principal Findings. We studied a total of 804 subjects, 489 of whom with angiographically proven severe CAD, with or without MI (n = 307; n = 182; respectively). An additive model considering ten common polymorphisms [Prothrombin 20210G.A, PAI-1 4G/5G, Fibrinogen b -455G.A, FV Leiden and ‘‘R2’’, FVII -402G.A and