association of polymorphisms of the chi3l1 gene with asthma and atopy a populations-based study of 6514 danish adults协会chi3l1基因的多态性与哮喘和特异反应性populations-based 6514年丹麦成人的研究.pdf

Association of Polymorphisms of the CHI3L1 Gene with Asthma and Atopy: A Populations-Based Study of 6514 Danish Adults 1 2 3 2,4 Camilla Noelle Rathcke *, Johan Holmkvist , Lise Lotte N. Husmoen , Torben Hansen , Oluf Pedersen2,5,6, Henrik Vestergaard1,6, Allan Linneberg3 1 Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark, 2 Hagedorn Research Institute, Steno Diabetes Center, Gentofte, Denmark, 3 Research Centre for Prevention and Health, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark, 4 Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark, 5 Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark, 6 Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Abstract Background: YKL-40 is a chitinase-like glycoprotein encoded by the chitinase 3-like 1 gene, CHI3L1, localized at chromosome 1q32.1. Increased levels of serum YKL-40 have been reported to be a biomarker for asthma and a reduced lung function. Interestingly, the C-allele of the -131 CRG (rs4950928) polymorphism of CHI3L1 has been shown to associate with bronchial hyperresponsiveness and reduced lung function suggesting that variations in CHI3L1 may influence risk of asthma. The objective of the present study was to investigate the association of common variation in the CHI3L1 locus with asthma, atopy and lung function in a large population-based sample of adults. Methods/Principal Findings: Eleven single nucleotide polymorphisms (SNPs) of CHI3L1 including rs4950928 were genotyped in 6514 individuals. Asthma was defined as self-reported history