the association between genetic variations of chi3l1, levels of the encoded glycoprotein ykl-40 and the lipid profile in a danish populationchi3l1基因变异之间的联系,水平的编码糖蛋白ykl-40丹麦人口和血脂.pdf

The Association between Genetic Variations of CHI3L1, Levels of the Encoded Glycoprotein YKL-40 and the Lipid Profile in a Danish Population 1 2 3 3 Stine Brinkløv Thomsen *, Camilla Noelle Rathcke , Tea Skaaby , Allan Linneberg , Henrik Vestergaard1,4 1 Center of Endocrinology and Metabolism, Dept. of Medicine, Copenhagen University Hospital, Herlev, Denmark, 2 Department of Cardiology, Nephrology and Endocrinology, Copenhagen University Hospital Hillerød, Denmark, 3 Research Centre for Prevention and Health, Copenhagen University Hospital, Glostrup, the Capital Region of Denmark, 4 Faculty of Health Sciences, University of Copenhagen, Denmark Abstract Background: The inflammatory biomarker YKL-40 seems to play a role in atherosclerosis and is elevated in patients with obesity, cardiovascular disease and type 2 diabetes. Single nucleotide polymorphisms (SNPs) of the YKL-40 encoding gene, CHI3L1, are associated with inter-individual YKL-40 levels. One study has described an association between a promoter polymorphism of CHI3L1 and levels of low density lipoprotein. The objective of this study was to evaluate the influence of YKL-40 on lipid parameters by determining the association between polymorphisms of CHI3L1, serum YKL-40 and levels of the differentiated lipid profile in a Danish general population. Methodology/Principle Findings: 12 SNPs of CHI3L1 were genotyped, and serum YKL-40 and parameters of the lipid profile were measured in 2,656 Danes. Lipid profile and genotypes were available in another Danish population (n = 6,784) for replication. Cholesterol and triglyceride levels increased with increasing YKL-40 quartile (both p,0.0001), and YKL-40 correlated with triglyceride levels (b = 0.15, p,0.0001). Low