association between variants of the leptin receptor gene (lepr) and overweight a systematic review and an analysis of the colaus study瘦素受体基因的变体之间的联系(lepr)和超重的系统回顾和colaus的分析研究.pdf

Association between Variants of the Leptin Receptor Gene (LEPR) and Overweight: A Systematic Review and an Analysis of the CoLaus Study 1,2 ¨ 1 3 4 ´ 4 Nicole Bender *, Noemi Allemann , Diana Marek , Peter Vollenweider , Gerard Waeber , Vincent 5 1 6 Mooser , Matthias Egger , Murielle Bochud 1 Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland, 2 Institute for Human Evolution, University of the Witwatersrand, Johannesburg, South Africa, 3 Department of Medical Genetics, Swiss Institute of Bioinformatics, University of Lausanne, Switzerland, Lausanne, Switzerland, 4 Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 5 GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America, 6 Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland Abstract Background: Three non-synonymous single nucleotide polymorphisms (Q223R, K109R and K656N) of the leptin receptor gene (LEPR) have been tested for association with obesity-related outcomes in multiple studies, showing inconclusive results. We performed a systematic review and meta-analysis on the association of the three LEPR variants with BMI. In addition, we analysed 15 SNPs within the LEPR gene in the CoLaus study, assessing the interaction of the variants with sex. Methodology/Principal Findings: We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated