association of secondhand smoke exposure with pediatric invasive bacterial disease and bacterial carriage a systematic review and meta-analysis协会的二手烟暴露与儿童侵袭性细菌性疾病和细菌马车系统回顾和荟萃分析.pdf

Association of Secondhand Smoke Exposure with Pediatric Invasive Bacterial Disease and Bacterial Carriage: A Systematic Review and Meta-analysis 1,2 1 3 4,5,6,7 Chien-Chang Lee , Nicole A. Middaugh , Stephen R. C. Howie , Majid Ezzati * 1 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan, 3 Bacterial Diseases Programme, Medical Research Council (UK) Laboratories, Fajara, The Gambia, 4 Department of Global Health and Population, Harvard School of Public Health, Boston, Massachusetts, United States of America, 5 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, 6 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom, 7 MRC-HPA Center for Environment and Health, Imperial College, London, United Kingdom Abstract Background: A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngeal carriage of bacteria, for Neisseria meningitidis (N. meningitidis), Haemophilus influenzae type B (Hib), and Streptococcus pneumoniae (S. pneumoniae). Methods and Findings: Two independent reviewers searched Medline, EMBASE, and selected other databases, and screened articles for inclusion and exclusion criteria. We identified 30 case-control studies on SHS and IBD, and 12 cross-