association between smoking and latent tuberculosis in the u.s. population an analysis of the national health and nutrition examination survey联系吸烟和潜在结核的美国人口的分析国家健康与营养考试调查.pdf

Association between Smoking and Latent Tuberculosis in the U.S. Population: An Analysis of the National Health and Nutrition Examination Survey 1 1 1,2 3,4 1 1. David J Horne *, Monica Campo , Justin R Ortiz , Eyal Oren , Matthew Arentz , Kristina Crothers , Masahiro Narita1,3,4. 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington, United States of America, 2 Department of Global Health, University of Washington, Seattle, Washington, United States of America, 3 Public Health - Seattle King County, TB Control Program, Seattle, Washington, United States of America, 4 Department of Epidemiology, University of Washington, Seattle, Washington, United States of America Abstract Background: Evidence of an association between cigarette smoking and latent tuberculosis infection (LTBI) is based on studies in special populations and/or from high prevalence settings. We sought to evaluate the association between LTBI and smoking in a low prevalence TB setting using population-based data from the National Health and Nutrition Examination Survey (NHANES). Methods: In 1999–2000, NHANES assessed LTBI (defined as a tuberculin skin test measurement $10 mm) in participants, and those $20 years of age were queried regarding their tobacco use and serum cotinine was measured. We evaluated the association of LTBI with self-reported smoking history and smoking intensity in multivariable logistic regression models that adjusted for known confounders (gender, age, birthplace, race/ethnicity, poverty, education, history of BCG vaccination, and history of household exposure to tuberculosis disease). R