association between dna damage response and repair genes and risk of invasive serous ovarian cancerdna损伤反应和修复基因之间的联系和侵入性浆液性卵巢癌的风险.pdf

Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer 1,2 2,3 3 3 Joellen M. Schildkraut *, Edwin S. Iversen , Melanie A. Wilson , Merlise A. Clyde , Patricia G. 1,2 4 5 6 2,7,8 Moorman , Rachel T. Palmieri , Regina Whitaker , Rex C. Bentley , Jeffrey R. Marks , Andrew Berchuck2,5,8 1 Departments of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, 2 The Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America, 3 Department of Statistical Science, Duke University Medical Center, Durham, North Carolina, United States of America, 4 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America, 5 Obstetrics and Gynecology/Division of Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina, United States of America, 6 Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, 7 Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America, 8 Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America Abstract Background: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population- based, case-con