association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccinationtoll样受体信号通路中的基因交流协会和百日咳疫苗的抗体反应.pdf

Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination 1,2 1 3 1 4 Tjeerd G. Kimman *, Sander Banus , Naomi Reijmerink , Johan Reimerink , Foekje F. Stelma , Gerard H. 5 6 3 7 Koppelman , Carel Thijs , Dirkje S. Postma , Marjan Kerkhof 1 Center for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, 2 Central Veterinary Institute, Lelystad, The Netherlands, 3 Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 4 Department of Medical Microbiology, Academic Hospital Maastricht, Maastricht, The Netherlands, 5 Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 6 Department of Epidemiology, School of Public Health and Primary Care (Caphri), and Nutrition and Toxicology Research Institute Maastricht (Nutrim), Maastricht University, Maastricht, The Netherlands, 7 Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract Background: Activation of the Toll-like receptor (TLR) signaling pathway through TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4-mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps. We examined whether single nucleotide polymorphisms (SNPs) in genes of the TLR4 pathway and their interaction are associated with the resp