cost-effectiveness of adolescent pertussis vaccination for the netherlands using an individual-based dynamic model荷兰青少年百日咳疫苗的成本效益使用一个基于单独的动态模型.pdf

Cost-Effectiveness of Adolescent Pertussis Vaccination for The Netherlands: Using an Individual-Based Dynamic Model 1 2,3 4 5 Robin de Vries *, Mirjam Kretzschmar , Joop F. P. Schellekens , Florens G. A. Versteegh , Tjalke A. 1 6 1 Westra , John J. Roord , Maarten J. Postma 1 Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands, 2 Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 3 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands, 4 Laboratory for Infectious Diseases, Groningen, The Netherlands, 5 Department of Pediatrics, Groene Hart Ziekenhuis, Gouda, The Netherlands, 6 Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands Abstract Background: Despite widespread immunization programs, a clear increase in pertussis incidence is apparent in many developed countries during the last decades. Consequently, additional immunization strategies are considered to reduce the burden of disease. The aim of this study is to design an individual-based stochastic dynamic framework to model pertussis transmission in the population in order to predict the epidemiologic and economic consequences of the implementation of universal booster vaccination programs. Using this framework, we estimate the cost-effectiveness of universal adolescent pertussis booster vaccination at the age of 12 years in the Netherlands. Methods/Principal