the effect of toll-like receptor 4 in the aqueous humor of endotoxin-induced uveitistoll样受体的影响4 endotoxin-induced房水的葡萄膜炎.pdf

Int. J. Mol. Sci. 2012, 13, 2110-2118; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis Jing Wang 1, Hong Lu 1,*, Yingzhi Xu 1, Xiaofeng Hu 1, Wei Chen 2 and Shang Li 1 1 Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China; E-Mails: daxi666@163.com (J.W.); xiaoting_5@126.com (Y.X.); drhuxiaofeng@ (X.H.); lishangmanager@ (S.L.) 2 Department of Ophthalmology, Haidian Maternal and Child Health Hospital, Tongji Medical University, Beijing 100080, China; E-Mail: chenweidgj@ * Author to whom correspondence should be addressed; E-Mail: honglu111@; Tel: +86-10-8523-1488; Fax: +86-10-8523-1210. Received: 6 January 2012; in revised form: 6 February 2012 / Accepted: 10 February 2012 / Published: 16 February 2012 Abstract: In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with