the effect of lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats枸杞多糖的影响在老鼠饮酒导致的氧化应激.pdf

Molecules 2011, 16, 2542-2550; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Effect of Lycium Barbarum Polysaccharide on Alcohol-Induced Oxidative Stress in Rats Daye Cheng 1,* and Hong Kong 2 1 Department of Transfusion, The First Hospital of China Medical University, Shenyang, Liaoning Province, China 2 Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang , Liaoning Province, China; E-Mail: konghong_cmu@ * Author to whom correspondence should be addressed; E-Mail: dayecheng_cmu@; Tel.: +86-24 Fax: +86-24 Received: 9 February 2011; in revised form: 10 March 2011 / Accepted: 14 March 2011 / Published: 17 March 2011 Abstract: The aim of this study was to investigate the effects of Lycium barbarum Polysaccharide (LBP) on alcohol-induced liver damage in rats. A total of 36 rats were divided into control, ethanol and ethanol + LBP groups. Rats in the ethanol group were fed 7 g ethanol/kg body weight by gastric infusion, three times a day, for 30 consecutive days, while rats in the control group received the same volume of physiological saline instead of ethanol, and rats in ethanol + LBP group were fed both ethanol (7 g/kg body weight) and LBP (300 mg/Kg body weight/day). Alcoholic liver injury was examined by serum ALT and AST activities, alcoholic fatty liver was assessed by lipid levels, and oxidative stress was evaluated by SOD, CAT, GSH-Px, GSH an