the effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats长期严重缺硒的影响对铁和锌的数量在老鼠的器官.pdf

Molecules 2009, 14, 4440-4453; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats 1,2 1 1 1 1 Ken-ichiro Matsumoto , Sachiyo Terada , Marie Ariyoshi , Aya Okajo , Atsushi Hisamatsu , Iori Ui 1 and Kazutoyo Endo 1,* 1 Department of Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi- Tamagawagakuen, Machida-shi, Tokyo 194-8543, Japan; E-Mail: matsumok@nirs.go.jp (K.M.) 2 Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan * Author to whom correspondence should be addressed; E-Mail: kazutoyo@ac.shoyaku.ac.jp; Tel.: +81-42-721-1565; Fax: +81-42-721-1541. Received: 5 October 2009; in revised form: 2 November 2009 / Accepted: 4 November 2009 / Published: 5 November 2009 Abstract: The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of non- lethal c