the effect of fast created inbreeding on litter size and body weights in mice快速创建近亲繁殖的影响在老鼠窝大小和身体重量.pdf

Genet. Sel. Evol. 37 (2005) 523–537 523 c INRA, EDP Sciences, 2005 DOI: 10.1051/gse:2005014 Original article The effect of fast created inbreeding on litter size and body weights in mice ∗ Marte H , Theo M, Odd V Department of Animal and Aquacultural Sciences, University of life sciences, 1432 Ås, Norway (Received 7 September 2004; accepted 24 March 2005) Abstract – This study was designed to reveal any differences in effects of fast created versus total inbreeding on reproduction and body weights in mice. A line selected for large litter size for 124 generations (H) and a control line (K) maintained without selection for the same num- ber of generations were crossed (HK) and used as a basis for the experiment. Within the HK cross, full sib, cousin or random mating were practised for two generations in order to create new inbreeding (IBF ) at a fast rate. In the first generation of systematic mating, old inbreeding was regenerated in addition to creation of new inbreeding from the mating design giving total inbreeding (IBT ). The number of pups born alive (NBA) and body weights of the animals were then analysed by a model including both IB and IB . The IB of the dam was in the present T F T study found to reduce the mean NBA with –0.48 (±0.22) (p 0.05) pups per 10% increas