the effect of self-assembling peptide rada16-i on the growth of human leukemia cells in vitro and in nude mice的影响自组装肽rada16-i在人类白血病细胞体外生长的裸小鼠.pdf

Int. J. Mol. Sci. 2009, 10, 2136-2145; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article The Effect of Self-Assembling Peptide RADA16-I on the Growth of Human Leukemia Cells in Vitro and in Nude Mice Chengkang Tang 1, Ximing Shao 1, Binbin Sun 1, Wenli Huang 1 and Xiaojun Zhao 1,2,3,* 1 Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, 610041, China; E-Mails: tangck@126.com (C.T.); shaoximing07@163.com (X.S.); sunbb@163.com (B.S.); huangwenli133@163.com (W.H.) 2 West China Medical School, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu, 610041, Chengdu, China 3 Center for Biomedical Engineering, NE47-379, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA * Author to whom correspondence should be addressed; E-mails: xiaojunz@; Tel. +86-28-8516-4069; Fax: +86-28-8516-4070 Received: 31 March 2009; in revised form: 30 April 2009 / Accepted: 12 May 2009 / Published: 14 May 2009 Abstract: Nanofiber scaffolds formed by self-assembling peptide RADA16-I have been used for the study of cell proliferation to mimic an extracellular matrix. In this study, we investigated the effect of RADA16-I on the growth of human leukemia cells in vitro and in nude mice. Self-assembly assessment showed that RADA16-I molecules have excellent self-assembling ability to form stable nanofiber