the effect of uncertainty in exposure estimation on the exposure-response relation between 1,3-butadiene and leukemia暴露评估的不确定性的影响我们关系1,三丁基和白血病.pdf

Int. J. Environ. Res. Public Health 2009, 6, 2436-2455; doi:10.3390/ijerph6092436 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article The Effect of Uncertainty in Exposure Estimation on the Exposure-Response Relation between 1,3-Butadiene and Leukemia John J. Graff 1,2,*, Nalini Sathiakumar 2, Maurizio Macaluso 2,3, George Maldonado 4, 2 2 Robert Matthews and Elizabeth Delzell 1 Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI 48201, USA 2 University of Alabama at Birmingham School of Public Health, Department of Epidemiology, Birmingham, AL 35294, USA; E-Mails: nalini@ (N.S.); rsm@ (R.M.); edelzell@ (E.D.) 3 Centers for Disease Control and Prevention, Division of Reproductive Health, Atlanta, GA 30341, USA; E-Mail: mum0@ 4 University of Minnesota School of Public Health, Division of Environmental Health Sciences, Minneapolis, MN 55455, USA; E-Mail: gmphd@ * Author to whom correspondence should be addressed; E-Mail: graffj@; Tel.: +1 313-578-4205; Fax: +1 313-578-4306. Received: 16 July 2009 / Accepted: 8 September 2009 / Published: 11 September 2009 Abstract: In a follow-up study of mortality among North American synthetic rubber industry workers, cumulative exposure to 1,3-butadiene was posit