the effects of arsenic trioxide on dna synthesis and genotoxicity in human colon cancer cells三氧化二砷的影响在人类结肠癌细胞dna合成和基因毒性.pdf

Int. J. Environ. Res. Public Health 2010, 7, 2018-2032; doi:10.3390/ijerph7052018 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article The Effects of Arsenic Trioxide on DNA Synthesis and Genotoxicity in Human Colon Cancer Cells Jacqueline J. Stevens 1,*, Barbara Graham 2, Alice M. Walker 2, Paul B. Tchounwou 2 and 2 Christian Rogers 1 Molecular and Cellular Biology Research Laboratory, NIH-Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, 1400 JR Lynch Street, Box 18540, Jackson, MS 39217, USA 2 Molecular Toxicology Research Laboratory, NIH-Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, 1400 JR Lynch Street, Box 18540, Jackson, MS 39217, USA; E-Mails: barbara.e.graham@ (B.G.); alice.m.walker@ (A.M.W.); paul.b.tchounwou@ (P.B.T.); christian.s.rogers@ (C.R.) * Author to whom correspondence should be addressed; E-Mail: Jacqueline.j.stevens@; Tel: +1-601-979-3462; Fax: +1-601-979-5842. Received: 8 January 2010; in revised form: 26 February 2010 / Accepted: 3 April 2010 / Published: 28 April 2010 Abstract: Colon cancer is the third leading cause of cancer-related deaths worldwide. Recent studies in our laboratory