cytotoxicity on human cancer cells of ophidiacerebrosides isolated from the african starfish narcissia canariensis在人类癌症细胞的细胞毒性ophidiacerebrosides孤立的非洲海星narcissia canariensis.pdf

Mar. Drugs 2010, 8, 2988-2998; doi:10.3390/md8122988 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Cytotoxicity on Human Cancer Cells of Ophidiacerebrosides Isolated from the African Starfish Narcissia canariensis 1 1 2 1 Fereshteh Farokhi , Gaetane Wielgosz-Collin , Monique Clement , Jean-Michel Kornprobst and Gilles Barnathan 1,* 1 Research Group Sea, Molecules and Health EA 2160, College of Pharmacy, University of Nantes, 1 rue Gaston Veil, BP 53508, F-44035 Nantes Cedex 01, France; E-Mails: fereshteh.farokhi@etu.univ-nantes.fr (F.F.); wielgosz-collin@univ-nantes.fr (G.W.-C.); kornprobst.jean-michel@neuf.fr (J.-M.K.) 2 INSERM CRNA U892, 8 quai Moncousu, BP 70721, F-44007 Nantes Cedex, France; E-Mail: monique.clement@univ-nantes.fr (M.C.) * Author to whom correspondence should be addressed; E-Mail: gilles.barnathan@univ-nantes.fr; Tel.: +33-2-5112-5689; Fax: +33-2-5112-5679. Received: 5 November 2010; in revised form: 6 December 2010 / Accepted: 20 December 2010 / Published: 22 December 2010 Abstract: The starfish Narcissia canariensis harvested from the coasts off Dakar, Senegal, was investigated for glycolipids (GL). This report deals with the isolation, characterization and biological activity of a fraction F13-3 separated from the GL mixture and selected according to its ability to inhibit KB cell proliferation after 72 hours of treatment. Firstly, a GL