xzh-5 inhibits stat3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cellsxzh-5抑制stat3磷酸化和增强细胞毒性化疗药物在人类乳腺癌和胰腺癌细胞.pdf
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XZH-5 Inhibits STAT3 Phosphorylation and Enhances the
Cytotoxicity of Chemotherapeutic Drugs in Human
Breast and Pancreatic Cancer Cells
1,2 2¤ 4 1 2,5 2 4 6
Aiguo Liu *, Yan Liu , Zhigang Jin , Qun Hu , Li Lin , David Jou , Jing Yang , Zhenghu Xu ,
6 7 2,3
Hong Wang , Chenglong Li , Jiayuh Lin *
1 Department of Pediatrics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China, 2 Center for Childhood Cancer,
The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, United States of America, 3 Molecular, Cellular and Developmental Biology Program, The Ohio
State University, Columbus, Ohio, United States of America, 4 Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-
Champaign, Urbana, Illinois, United States of America, 5 Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and
Technology, Wuhan, Hubei, People’s Republic of China, 6 Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, United States of America, 7 Division
of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
Abstract
Constitutive activation of Signal Transducers and Activators of Transcription 3 (STAT3) signaling is frequently detected in
breast and pancreatic cancer. Inhibiting constitutive STAT3 signaling represents a promising molecular target for
therapeutic approach. Using structure-based design, we developed a non-peptide cell-permeable, small molecule, termed
as XZH-5, which targeted STAT3 phosphor
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