the ectopic expression of brca1 is associated with genesis, progression, and prognosis of breast cancer in young patientsbrca1的异位表达与起源、发展,并在年轻患者乳腺癌的预后.pdf

Zhang et al. Diagnostic Pathology 2012, 7:181 /content/7/1/181 RESEARCH Open Access The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients * Qingli Zhang , Qinghui Zhang, Hua Cong and Xiaoli Zhang Abstract Objective: The study is to explore the histopathological features and the molecular marker expression of young women with breast cancers. Methods: The pathological data of 367 cases of female breast cancer patients were retrospectively analyzed, focusing on the analysis of young breast cancer incidence trends and the clinical and pathological features. Results: Compared with elderly breast cancer patients, young women with breast cancers had larger tumor sizes, higher histological grades, and lymph node metastasis rates. The majority of patients were in the PTNM III stage, with the clinical and pathological features of strong invasiveness. The positive expression rate of the BRCA1 protein in the young group was higher than that in the old group. BRCA1 expression was positively correlated with the PTNM stage and axillary lymph node metastasis (P 0.05). Conclusions: The ectopic expression of BRCA1 is associated with the genesis, progression, and prognosis of young breast cancer patients. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/1628000054838044 Keywords: BRCA1, WWOX, Gene detection Introduction important role in maintaining gene stability [3], with its Breast cancer has become one of the common diseases mutation being related with 35%-40% of familial breast that seriously threaten women health. From 1982 to cancers and ova