superoxide enhances the antitumor combination of admnsod plus bcnu in breast cancer超氧化物增强的抗肿瘤结合admnsod + bcnu在乳腺癌.pdf

Cancers 2010, 2, 68-87; doi:10.3390/cancers2010068 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer 1 1 1 1 1 Wenqing G. Sun , Christine J. Weydert , Yuping Zhang , Lei Yu , Jingru Liu , 1 1,2, 1 Douglas R. Spitz , Joseph J. Cullen * and Larry W. Oberley 1 Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Iowa City, IA, USA; E-Mails: wenqing-sun@ (W.S.); weydertc@ (C.W.); yuping-zhang@ (Y.Z.); lei-yu-1@ (L.Y.); jingru-liu@ (J.L.); douglas-spitz@ (D.S.) 2 Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa and the VA Medical Center, Iowa City, IA, USA * Author to whom correspondence should be addressed; E-Mail: joseph-cullen@; Tel.: +1-319-353-8297; Fax: +1-319-335-8039. Received: 21 December 2009; in revised form: 9 February 2010 / Accepted: 10 February 2010 / Published: 12 February 2010 Abstract: Overexpression of manganese superoxide dismutase (MnSOD) can sensitize a variety of cancer cell lines to many anticancer drugs. Recent work has shown that cancer cells can be sensitized to cell killing by raising peroxide levels through increased manganese superoxide dismutase (MnSOD) when combined with inhibition of peroxide