structural consideration in designing organotin polyethers to arrest the growth of breast cancer cells in vitro结构设计中考虑有机锡聚醚逮捕乳腺癌细胞体外的生长.pdf

Materials 2011, 4, 801-815; doi:10.3390/ma4040801 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro Charles E. Carraher Jr. 1,2, Michael R. Roner 3,*, Kimberly Shahi 4 and Girish Barot 5 1 Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA; E-Mail: carraher@ (C.E.C.) 2 Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA 3 Department of Biology, University of Texas Arlington, Arlington, TX 760 19, USA 4 Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA; E-Mail: kimberly.shahi@ (K.S.) 5 Department of Biology, Boston University, Boston, MA 02215, USA; E-Mail: girishbarod@ (G.B.) * Author to whom correspondence should be addressed : E-Mail: roner@; Tel.: +1-817-272-1302. Received: 11 February 2011; in revised form: 4 April 2011 / Accepted: 8 April 2011 / Published: 15 April 2011 Abstract: The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inh