the effects of artesunate on the expression of egfr and abcg2 in a549 human lung cancer cells and a xenograft model青蒿琥酯的影响对表皮生长因子受体的表达和abcg2在人类肺癌细胞a549和异种移植模型.pdf

Molecules 2011, 16, 10556-10569; doi:10.3390/molecules161210556 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model Hu Ma 1,2, Quan Yao 1, An-Mei Zhang 1, Sheng Lin 1, Xin-Xin Wang 1, Lei Wu 1, Jian-Guo Sun 1,* and Zheng-Tang Chen 1,* 1 Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Xinqiao Street No. 2, Chongqing 400037, China 2 Department of Oncology, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China * Authors to whom correspondence should be addressed; E-Mails: sunjg09@ (J.-G.S.); chenztang@ (Z.-T.C.); Tel.: +86-23-6875-5626. Received: 31 October 2011; in revised form: 25 November 2011 / Accepted: 5 December 2011 / Published: 19 December 2011 Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Clinical and laboratory studies have suggested that multi-targeting approaches against neoplastic cells could help to increase patient survival and might reduce the emergence of cells that are resistant to single-target inhibitors. Artesunate (ART) is one of the most potent and rapidly acting antimalarial agents known, and it also exerts a profound cytotoxic activity toward cancer cells and reverses multi-drug resistance. In the present study, we found that artesunate inhibited NSCLC A549 cell growth and proliferation, induced apoptosis and suppressed tu