the effects of artesunate on the expression of egfr and abcg2 in a549 human lung cancer cells and a xenograft model青蒿琥酯的影响对表皮生长因子受体的表达和abcg2在人类肺癌细胞a549和异种移植模型.pdf
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Molecules 2011, 16, 10556-10569; doi:10.3390/molecules161210556
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
The Effects of Artesunate on the Expression of EGFR and
ABCG2 in A549 Human Lung Cancer Cells and
a Xenograft Model
Hu Ma 1,2, Quan Yao 1, An-Mei Zhang 1, Sheng Lin 1, Xin-Xin Wang 1, Lei Wu 1,
Jian-Guo Sun 1,* and Zheng-Tang Chen 1,*
1 Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Xinqiao Street No. 2,
Chongqing 400037, China
2 Department of Oncology, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China
* Authors to whom correspondence should be addressed; E-Mails: sunjg09@ (J.-G.S.);
chenztang@ (Z.-T.C.); Tel.: +86-23-6875-5626.
Received: 31 October 2011; in revised form: 25 November 2011 / Accepted: 5 December 2011 /
Published: 19 December 2011
Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death
worldwide. Clinical and laboratory studies have suggested that multi-targeting approaches
against neoplastic cells could help to increase patient survival and might reduce the
emergence of cells that are resistant to single-target inhibitors. Artesunate (ART) is one of
the most potent and rapidly acting antimalarial agents known, and it also exerts a profound
cytotoxic activity toward cancer cells and reverses multi-drug resistance. In the present
study, we found that artesunate inhibited NSCLC A549 cell growth and proliferation,
induced apoptosis and suppressed tu
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