study of the anti-proliferative activity of 5-substituted 4,7-dimethoxy-1,3-benzodioxole derivatives of sy-1 from antrodia camphorata on human colo 205 colon cancer cells英文论文.pdf

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 450529, 8 pages doi:10.1093/ecam/nep230 Original Article Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells Hsiu-Man Lien,1, 2 Po-Tsun Kuo,3 Chao-Lu Huang,4 Jung-Yie Kao,3 Ho Lin,4 Ding-Yah Yang,1 and Ya-Yun Lai5, 6 1 Department of Chemistry, Tunghai University, Taichung, Taiwan 2 Yusheng Biotechnology Co. Ltd., Taichung, Taiwan 3 Institute of Biochemistry, College of Life Science, National Chung Hsing University, Taichung, Taiwan 4 Department of Life Science, National Chung Hsing University, Taichung, Taiwan 5 Department of Applied Chemistry, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung 402, Taiwan 6 Department of Biochemistry, Chung Shan Medical University Hospital, Taichung, Taiwan Correspondence should be addressed to Ya-Yun Lai, yayun819@.tw Received 27 July 2009; Accepted 25 November 2009 Copyright © 2011 Hsiu-Man Lien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A set of 10 4,7-dimethoxy-1,3-benzodioxole derivatives based on a lead compound previously discovered by our group, SY-1, which was isolated from Antrodia camphorata, were evaluated for their in vitro inhibitory activity on human colorectal carcinoma cells (COLO 205). Structure-activity relationship studies of the 10 compounds indicated the importance of the chain length of the alkyl group at the 5-position, and the 2-propenyl substituent named “apiole” exhibited the most pote