the apoptotic effect of 1’s-1’-acetoxychavicol acetate from alpinia conchigera on human cancer cells1是1的凋亡效应的醋酸-acetoxychavicol conchigera成分对人体癌细胞.pdf

Molecules 2010, 15, 8048-8059; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Apoptotic Effect of 1’S-1’-Acetoxychavicol Acetate from Alpinia Conchigera on Human Cancer Cells Khalijah Awang 1,*, Mohamad Nurul Azmi 1, Lionel In Lian Aun 2, Ahmad Nazif Aziz 3, 4 2 Halijah Ibrahim and Noor Hasima Nagoor 1 Centre for Natural Product Research and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: libra_mine85@yahoo.co.uk (M.N.A.) 2 Institute of Biological Sciences (Genetics Molecular Biology), Faculty of Science, University Malaya, 50603, Kuala Lumpur, Malaysia; E-Mails: lionelin_81@ (L.I.L.A.); hasima@.my (N.H.N.) 3 Department of Chemical Science, Faculty of Science and Technology, University Malaysia Terengganu, Mengabang Telipot, 2103, Kuala Terengganu, Malaysia; E-Mail: nazif@.my (A.N.A.) 4 Institute of Biological Sciences (Ecology and Biodiversity), Faculty of Science, University Malaya, 50603, Kuala Lumpur, Malaysia; E-Mail: ihalijah@.my (H.I.) * Author to whom correspondence should be addressed; E-Mail: khalijah@.my; Tel.: +603 Fax: +603 Received: 18 September 2010; in revised form: 8 October 2010 / Accepted: 16 October 2010 / Published: 9 November 2010 Abstract: 1’-(S)-1’-Acetoxychavicol acetate (ACA) isolated from the Malaysian ethno- medicinal plant Alpinia conchigera Griff. was investigated for its potential as an an