the effect of marathon on mrna expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners马拉松的mrna表达抗凋亡的影响以及pro-apoptotic蛋白质和sirtuins蛋白家族男性休闲长跑.pdf

Marfe et al. BMC Physiology 2010, 10:7 /1472-6793/10/7 RESEARCH ARTICLE Open Access Research article The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners 1 2 2 1 2 33 Gabriella Marfe* , Marco Tafani , Bruna Pucci , Carla Di Stefano , Manuela Indelicato , Angela, Angela AndreoliAndreoli ,, Matteo Antonio Russo2,4 1 5 , Paola Sinibaldi-Salimei and Vincenzo Manzi Abstract Background: A large body of evidence shows that a single bout of strenuous exercise induces oxidative stress inof strenuous exercise induces oxidative stress inof strenuous exercise induces oxidative stress in circulating human lymphocytes leading to lipid peroxidation, DNA damage, mitochondrial perturbations, and proteinon, DNA damage, mitochondrial perturbations, and proteinon, DNA damage, mitochondrial perturbations, and protein oxidation. ct of physical load on the extent of apoptosis in primary cells derived from In our research, we investigated the effect of physical load on the extent of apoptosis in primary cells derived from blood samples of sixteen healthy amateur runners after marathon (a.m.).eur runners after marathon (a.m.).eur runners after marathon (a.m.). ten healthy amateur runners peripher Results: Blood samples were collected from ten healthy amateur runners peripheral blood mononuclear cells (PBMCs) were isolated from whole blood