studies on the synthesis of derivatives of marine-derived bostrycin and their structure-activity relationship against tumor cells研究合成的衍生品marine-derived bostrycin及其构效关系对肿瘤细胞.pdf

Mar. Drugs 2012, 10, 932-952; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells Hong Chen 1,2, Lili Zhong 1,2, Yuhua Long 3, Jia Li 1,2, Jueheng Wu 2,4,5, Lan Liu 1,2, Shengping Chen 2,4,5, Yongcheng Lin 1,2, Mengfeng Li 2,4,5, Xun Zhu 2,4,5,* and Zhigang She 1,2,* 1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China; E-Mails: chenwexpo@ (H.C.); zhonglili42@ (L.Z.); nuekagami@163.com (J.L.); cesllan@ (L.L.); ceslyc@ (Y.L.) 2 Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China; E-Mails: wujh@ (J.W.); chenshp@ (S.C.); limf@ (M.L.) 3 School of Chemistry and Environment, South China Normal University, 348 West Outer Ring Road, Guangzhou 510006, China; E-Mail: longyh@ 4 Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China 5 Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China * Authors to whom correspondence should be addressed; E-Mails: zhuxun8@ (X.Z.); cesshzhg@ (Z.S.); Tel.: +86-20-8733-2748 (X.Z.); +86-20-8411-3356 (Z.S.); Fax: +86-20-8733-0209 (X.Z.); +86-20-8411-3356 (Z.S.). Received: 23 February 2012; in revised form: 10 April 2012 / Accepted: 12 April