synthesis and structure-activity correlation studies of metal complexes of α-n-heterocyclic carboxaldehyde thiosemicarbazones in shewanella oneidensis金属配合物的合成及构效关系研究α-n-heterocyclic carboxaldehyde thiosemicarbazones在shewanella oneidensis.pdf

Int. J. Environ. Res. Public Health 2005, 2(1), 170–174 International Journal of Environmental Research and Public Health ISSN 1660-4601 © 2005 by MDPI Synthesis and Structure-Activity Correlation Studies of Metal Complexes of α-N-heterocyclic Carboxaldehyde Thiosemicarbazones in Shewanella oneidensis 1* 2 1 1 Barbara A. Wilson , Ramaiyer Venkatraman , Cedrick Whitaker and Quintell Tillison 1Department of Biology/Genetics, College of Science, Engineering and Technology, Jackson State University, 1400 J.R. Lynch Street, P.O. Box 18540, Jackson, Mississippi, USA. 2Department of Chemistry, College of Science, Engineering and Technology, Jackson State University, 1400 J.R. Lynch Street, P.O. Box 18540, Jackson, Mississippi, USA. *Correspondence to Dr. Barbara A. Wilson. E-mail: barbara.a.wilson@ Received: 15 November 2004 / Accepted: 06 February 2005 / Published: 30 April 2005 Abstract: This investigation involved the synthesis of metal complexes to test the hypothesis that structural changes and metal coordination in pyridine thiosemicarbazones affect cell growth and cell proliferation in vitro. Thiosemicarbazones are well known to possess antitumor, antiviral, antibacterial, antimalarial, and other activities. Extensive research has been carried out on a