synthesis and structure-activity relationships of fenbufen amide analogsfenbufen酰胺类似物的合成及构效关系.pdf

Molecules 2010, 15, 8796-8803; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Structure-Activity Relationships of Fenbufen Amide Analogs Kun-I Lin 1,2, Chao-Hsun Yang 3, Chia-Wen Huang 1, Jhen-Yi Jian 3, Yu-Chun Huang 3,* and Chung-Shan Yu 1,4,* 1 Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu 30013, Taiwan; E-Mails: konyi@ (K.-I.L); chia-wen0827@.tw (C.-W.H). 2 Department of Obstetrics Gynecology, Chang Bing Show Chwan Memorial Hospital, Lukang Zhen, Changhua County, Taiwan 3 Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan; E-Mails: chyang@.tw (C.-H.Y.); lfil6169@ (J.-Y.J). 4 Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu, 300, Taiwan * Authors to whom correspondence should be addressed; E-Mails: ychuang@.tw (Y.-C.H.); csyu@.tw (C.-S.Y.). Received: 4 November 2010; in revised form: 29 November 2010 / Accepted: 1 December 2010 / Published: 2 December 2010 Abstract: The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10 to 100 μM. Methyl fenbufen amide had significant cytotoxic effects at a concentration of 100 μM. As the length of the alkyl amide side chain increased, the cytotoxic effects increased, and th